Showing posts with label opioid addiction. Show all posts
Showing posts with label opioid addiction. Show all posts

Wednesday, August 23, 2017

First Of Its Kind Study Shows Undeniable Evidence Cannabis Can Cure Opioid Addiction

opioid addiction

As the opioid epidemic rages on, those professing to seek “solutions” are willfully ignoring one of the most promising treatments – medical cannabis. When the Comprehensive Addiction & Recovery Act (CARA) was being debated in 2016, amendments to study medical cannabis were stripped out.


This happened despite studies showing that medical cannabis eases neuropathic pain, and the government’s own National Institutes of Health stating, “Medical marijuana products may have a role in reducing the use of opioids needed to control pain.”


There were also studies showing that deaths from opioids plummet in states with legal cannabis, and that 80 percent of cannabis users give up prescription pills. A Feb. 2017 study confirmed that opioid dependence and overdoses dropped significantly in medical cannabis states.


Advertisment



In January 2017, the National Academies of Science published an exhaustive review of the scientific literature and found that one of the most promising areas in medical cannabis is for the treatment of chronic pain.


But all of this falls on deaf ears to those in the pockets of Big Pharma, which is largely to blame for getting America hooked on opioids, as described in a Harvard analysis.



Now, a new experimental study has shown exactly how cannabis works to treat opioid addiction – by actually blocking the opioid reward in the brain.




“This study sought to determine whether the cannabis constituent cannabidiol attenuates the development of morphine reward in the conditioned place preference paradigm. Separate groups of mice received either saline or morphine in combination with one of four doses of cannabidiol using three sets of drug/no-drug conditioning trials. After drug-place conditioning, morphine mice displayed robust place preference that was attenuated by 10 mg/kg cannabidiol. Further, when administered alone, this dose of cannabidiol was void of rewarding and aversive properties. The finding that cannabidiol blocks opioid reward suggests that this compound may be useful in addiction treatment settings.”



The use of cannabidiol (CBD), one of two major active ingredients in cannabis, is even more promising for legalization effiorts because it does not produce the high that THC does. So prohibitionists who demonize cannabis’ intoxicating effect have no ammo when it comes to CBD. CBD can even be extracted from hemp, which is grown for its fiber used in thousands of manufacturing applications.



READ MORE:  Cops Fake Illegal Drug Checkpoints to Detain and Search Drivers who React to the Sign



Because it can’t get anyone high, CBD extracts are even being permitted for medical use in staunchly prohibitionist states such as Oklahoma and Utah, to treat children with intractable epilepsy.


States have been reluctant to approve opioid addiction as a valid condition for prescribing medical cannabis. Big Pharma, having already secured their grip on federal government, has undoubtedly been working over state governments to prevent cannabis from threatening their profits. They had a measure of success in Arizona, which failed vote for legalization after pharma companies donated heavily to anti-pot propaganda campaigns.


The new study showing how CBD blocks the opioid reward will certainly prompt more research. This, coupled with statistical evidence from medical cannabis states, should finally prove fatal to the irrationality of blocking cannabis for opioid addiction treatment.

Sunday, July 9, 2017

Taxpayers Funding Heroin Vaccine as Govt Keeps Cannabis Solution to Opioid Crisis Illegal

opioid


After 20 years of patented opioid painkillers flooding America thanks to the pharmaceutical industry and careless doctors, the United States finds itself in a raging opioid epidemic.


The numbers are telling: 80 percent of the global opioid supply is consumed in the U.S., representing about 300 million prescriptions in 2015 alone or “enough drugs to give every single American 64 Percocets or Vicodin.”


As pain pill prescriptions have surged, overdose deaths from these legal drugs now total about 15,000 every year. When people can’t afford patented pills anymore, they turn to heroin, which killed almost 13,000 people in 2015—a 23 percent increase in one year.


Meanwhile, Big Pharma rakes in $24 billion a year from prescription opioids. Fully aware of the problem they helped create, companies like Purdue Pharma—perhaps the most notorious pill pusher with its infamous OxyContin—are now selling patented “abuse-deterrent” painkillers. These are bringing billions more in profits to pharma companies, “even though there’s little proof they reduce rates of overdoses or deaths.”


Advertisment



Another questionable avenue for tackling the opioid problem is the development of an “addiction vaccine.” The National Institute on Drug Abuse (NIDA), a federal agency, is using taxpayer dollars to fund efforts for anti-drug vaccines, as described on their webpage.



“A successful anti-drug vaccine will induce an immune response that blocks the target drug from entering the brain.


A patient who has been vaccinated will obtain no reward or relief of craving from taking the target drug, and so will have reduced motivation to continue further in relapse.”



NIDA funded experiments at the Scripps Research Institute have resulted in a successful anti-heroin vaccine used on primates. In a July 3 press release, study author Kim Janda noted the research “validates our previous rodent data and positions our vaccine in a favorable light for anticipated clinical evaluation.”



READ MORE:  EXCLUSIVE: Good Cop Speaks Out Against Drug War, Blows Whistle on Chief -- So Now He"s Being Fired



If vaccines can save the lives of opioid addicts without causing harm to brain-body functions, that is apparently a good thing. The question is, who will profit from it? Will this taxpayer-funded research turn into patented products bringing billions of dollars to Big Pharma?



Federal government supports anti-drug vaccines and other methods, including “overdose-reversal interventions” such as Nalaxone and medications to treat opioid addiction, but there is one elephant in the room which it continues to ignore.


Medical cannabis.


The National Academy of Sciences recently analyzed the state of scientific research on medical cannabis and reported “conclusive evidence” for its success at treating chronic pain.



As The Free Thought Project has covered extensively, studies are proving the real-world potential for medical cannabis to help solve the opioid crisis. In August 2015 we reported on a study finding that deaths from painkillers plummet in states with legal cannabis.


This was only the beginning. A study released in July 2016 confirmed that opioid use declines dramatically in states with legal medical cannabis. Prescriptions for depression, seizure, nausea and anxiety also declined. In March 2017, an analysis of hospital records found that medical cannabis access reduces harm from opioid abuse among the population.


Although government may deny the benefits of medical cannabis, the people are well informed. In January 2016, we reported on a study finding that 80 percent of therapeutic cannabis users give up prescriptions pills for the healing plant. A study last week confirmed this phenomenon, reporting that nearly 100 percent of medical cannabis users are giving up prescription pills.



READ MORE:  Irony? Court Violates Cop"s Free Speech, Ruling that His License Plate Can"t Say "OINK"



Former “drug czar” Michael Botticelli admitted in October 2016 that “government hasn’t wholly supported research to really investigate what’s the potential therapeutic value [of cannabis].” Indeed, Congress has made sure to block any chance at medical cannabis being part of the solution to the opioid crisis.


While the feds gladly fund research for anti-drug vaccines and other medications to treat opioid abuse—meaning more patent potential for their Big Pharma buddies—the prohibition of cannabis remains in full effect. Tens of thousands die and suffer while the ludicrous war on a plant continues.



With cannabis’ proven efficacy at combating the opioid epidemic, the only criminal act being committed is lawmakers keeping prohibition in place.

Friday, June 30, 2017

How Misuse of a Single Paragraph Ended Up Killing 60,000 Americans Per Year

How Misuse of a Single Paragraph Ended Up Killing 60,000 Americans Per Year | writing | Big Pharma General Health Medical & Health Sleuth Journal Special Interests US News



Opioid addiction is at an all-time high in the U.S., and according to many addiction specialists, pain and hopelessness are primary drivers of this burgeoning crisis.1 Limiting the availability of opioids and making overdose-reversal drugs and treatment for drug addiction more readily available are part of the answer. But it’s not enough.


We have to take a much deeper look at the root of the problem. What is causing all this physical pain and emotional distress in the first place? Clearly, the U.S. health care system is grossly ineffective when it comes to addressing chronic health problems. Whether pain is promoting hopelessness or the other way around is difficult to ascertain, but the two appear to be closely intertwined and need to be addressed together.



Somehow or another, we need to refocus our efforts to create lives worth living, and improve access to and information about basic disease prevention, which begins with diet and basic lifestyle choices — the kind of information I’ve focused on with my newsletter and website.


That said, it’s worth looking at how use of prescription opioids ended up getting so out of control. Doing so will reveal an oft-ignored truth: Drug companies may, and often do, promote drugs that do more harm than good. After all, drugs are profit centers, and drug companies are first and foremost beholden to their shareholders — not patients — who expect to make a decent profit from their investments.


To maximize sales, drug companies may hide information, misinform and/or outright lie about their medicines, and this is precisely what happened with narcotic painkillers.


The Paragraph That Spawned the Opioid Crisis


In 1980, a five-sentence-long letter to the editor was published in the New England Journal of Medicine (NEJM), one of the most prestigious medical journals in the world. Under the headline “Addiction Rare in Patients Treated With Narcotics,” the short letter, written by Jane Porter, a graduate student at Boston University Medical Center, read:



“Recently, we examined our current files to determine the incidence of narcotic addiction in 39,946 hospitalized medical patients who were monitored consecutively. Although there were 11,882 patients who received at least one narcotic preparation, there were only four cases of reasonably well documented addiction in patients who had no history of addiction.




The addiction was considered major in only one instance. The drugs implicated were meperidine in two patients, Percodan in one, and hydromorphone in one. We conclude that despite widespread use of narcotic drugs in hospitals, the development of addiction is rare in medical patients with no history of addiction.”



This turned out to be a letter with dire repercussions for millions of people in the decades to come. As noted in The Atlantic, this letter to the editor ended up being “so routinely mis-cited” it took on “a life of its own.”2



“[NEJM] … is issuing a corrective. It’s a new study3 … from a team led by David Juurlink at the University of Toronto that tracked how the five-sentence letter passed through the game of academic citation … to become evidence that opioids are safe for chronic pain. In fact, it said no such thing,” The Atlantic notes.




“… Hershel Jick, a doctor at Boston University Medical Center, had a database of hospital records that he used to monitor side effects from drugs … Something, perhaps a newspaper article, got Jick interested in looking at addiction. So he asked a graduate student, Jane Porter, to help calculate how many patients in the database got addicted after being treated with pain medicines, and dashed off a letter to the [NEJM].




Its brevity was commensurate with the effort involved … But as it began to accrue citations, its findings also began to mutate. Porter and Jick had only looked at hospitalized patients in regimented settings, but that detail got lost in the push to prescribe opioids to patients at home — an entirely different scenario.”



Drug Companies Latched on to Evidence That Wasn’t


In the years to come, this letter to the editor (most letters do not undergo any kind of peer-review) became an oft-cited piece of evidence used by drug companies and pain specialists alike. In all, it’s been cited more than 600 times since its publication, serving as the basis of misleading and inaccurate statements such as: “[P]ain population with no abuse history is literally at no risk for addiction,” and “There have been studies suggesting that addiction rarely evolves in the setting of painful conditions.”4


A remarkable 80 percent of the articles citing Jick’s letter failed to include the facts that his data pertained specifically to hospitalized patients receiving the drugs on a short-term basis. You simply cannot assume that because a narcotic is safe to use in the short term under careful monitoring by hospital staff, it will be safe long-term, and without careful monitoring.


According to Juurlink, “It’s difficult to overstate the role of this letter. It was the key bit of literature that helped the opiate manufacturers convince front-line doctors that addiction is not a concern.”5


Purdue Pharma used it as the basis for its claim that opioid addiction affects less than 1 percent of patients treated with the drugs. In a recent interview with The Associated Press (AP),6 Jick said he was “mortified that that letter to the editor was used as an excuse to do what these drug companies did.” He also clarified that his letter “only referred to people getting opioids in the hospital for a short period of time and has no bearing on long-term outpatient use.”


Researchers and journalists were no better. While the findings detailed in the letter were exceptionally narrow and the “study” less than thorough, researchers and journalists started referring to it as “extensive,” citing it as a “landmark report.” In 2001, Time magazine reported:7



“Many physicians now concede that patients have been undermedicated for decades, suffering needlessly. One reason was concern that big doses of opiates could depress respiration, but a large part stemmed from an exaggerated fear that patients would become addicted.




This fear, which continues to hold sway over American medicine, is basically unwarranted. A landmark study … found that only four became addicted to the [narcotic] drugs they received as patients. ‘You don’t see cancer patients running around robbing shopping malls to support their habits,’ notes Carr.”



NEJM Issues First-Ever Warning on 40-Year-Old Editor’s Note


Following the publication of Juurlink’s investigation into the citation trail leading from Jick’s letter to all manner of false claims, NEJM has now added an editor’s note to the 1980 letter,8 saying, “For reasons of public health, readers should be aware that this letter has been ‘heavily and uncritically cited’ as evidence that addiction is rare with opioid therapy.”


NEJM editor, Dr. Jeffrey Drazen, explained his note to AP, saying, “People have used the letter to suggest that you’re not going to get addicted to opioids if you get them in a hospital setting. We know that not to be true.”9 The journal has also added a link from Jick’s letter to Juurlink’s new study — a move that should eliminate most misuse in the future. As noted by Juurlink:10



“In conclusion, we found that a five-sentence letter … was heavily and uncritically cited as evidence that addiction was rare with long-term opioid therapy. We believe that this citation pattern contributed to the North American opioid crisis by helping to shape a narrative that allayed prescribers’ concerns about the risk of addiction associated with long-term opioid therapy.




In 2007, the manufacturer of OxyContin and three senior executives pleaded guilty to federal criminal charges that they misled regulators, doctors and patients about the risk of addiction associated with the drug. Our findings highlight the potential consequences of inaccurate citation and underscore the need for diligence when citing previously published studies.”



60,000 Americans Overdosed in 2016


Opioid addiction and accidental overdoses are now taking a tremendous toll. According to U.S. Deputy Attorney General Rod Rosenstein, drug overdoses are now the leading cause of death among Americans under the age of 50!11 In 2015, more than 52,000 Americans died from some form of drug overdose; 33,000 of them involved some form of opioid.


Preliminary data for 2016 reveals that death toll is anywhere from 59,000 to 65,000.12 That’s a 19 percent increase in one year, and the largest annual increase of drug overdose deaths in U.S. history. Between 2014 and 2015, drug overdose deaths rose by 11 percent.13The most common drugs involved in prescription opioid overdose deaths include14 methadone, oxycodone (such as OxyContin®) and hydrocodone (such as Vicodin®).


Synthetic opioids like fentanyl are also being abused by a rising number of people. A recent article in The New York Times15 highlights the tragedy of Grant Seaver and Ryan Ainsworth, two 13-year-olds who died after taking the synthetic opioid U-47700, also known as “pinky.” They got the drug from a teenage friend who had bought it on the dark web using bitcoin.


The sheer potency of synthetic opioids make them ideal for mailing. A standard envelope can hold enough fentanyl to get 50,000 people high. And, while the dark web marketplace Silk Road was shut down in 2013, others have popped up in its place, allowing people who might otherwise not have access to narcotics get them through the mail.


Disturbingly, rising fentanyl addiction also poses novel risks to first responders, law enforcement and even drug-sniffing dogs. The drug is so potent (anywhere from 500 to 1,000 percent more potent than morphine) that inhaling just a few flakes can be lethal.


In Ohio, a police officer nearly died from exposure to a fentanyl-related compound. During a routine traffic stop, he noticed a bag of white powder in the car. He used gloves and a mask for protection at the scene, but didn’t notice he’d gotten some on his shirt. Later, when a colleague pointed out the powder on his uniform, he brushed it off with his bare hand.


An hour later, he collapsed and had to be treated with FOUR doses of naloxone. He was lucky and survived the ordeal. Many fentanyl users are not. Deadly overdoses involving fentanyl rose by 50 percent between 2013 and 2014, and another 72 percent between 2014 and 2015.


Other Opioid Facts and Statistics


To truly understand the enormity of America’s drug problem, consider the following:














Drug overdoses are the ninth leading cause of death in the U.S.


In 2015, 52,404 Americans died from drug overdoses; 33,091 of them involved an opioid and nearly one-third of them, 15,281, of them were by prescription.16,17,18 Meanwhile, kidney disease, listed as the ninth leading cause of death on the CDC’s top 10 list, killed 48,146.19


The CDC does not include drug overdoses on this list, but if you did, drug overdoses (63 percent of which are opioids), would replace kidney disease as the ninth leading cause of death as of 2015, inching its way toward the eighth slot, currently occupied by respiratory complications such as pneumonia, which took 55,227 lives in 2015. As noted earlier, in the 50-and-younger demographic, drug overdoses are now the No. 1 cause of death.20



Opioid use has overtaken smoking


More Americans now use prescription opioids than smoke cigarettes.21 One in 4 Americans (and 1 in 3 millennials) reports knowing someone addicted to opioids.22



Opioids kill more Americans than car crashes


In 2014, prescription drug overdoses, a majority of which involved some type of opioid, killed more Americans than car crashes (49,714 compared to 32,675).23 This held true for 2015 as well, despite 2015 being hailed as the deadliest driving year since 2008. In all, 38,300 Americans died in car crashes in 201524 — a sharp rise thought to be related to a combination of cheaper gas prices and hence increased travel, and using smartphones while driving.25



Drugged driving causes more fatal crashes than drunk driving


Driving under the influence of opioids and other drugs has become a serious problem, now causing more fatal car crashes than drunk driving.26 Prescription and/or illegal drugs were involved in 43 percent of fatal car crashes in 2015, while 37 percent involved illegal amounts of alcohol.


Opioids, specifically, can increase your risk of being involved in a car crash by a factor of 10, having a relative car crash risk between 2 and 10.27 (A driver with no drugs or alcohol in their system has a relative crash risk of 1.)



Americans use 80 percent of global opioid supply


Prescriptions for opioid painkillers rose by 300 percent between 2000 and 2009,28,29 and Americans now use 80 percent of all the opioids sold worldwide.30 In Alabama, which has the highest opioid prescription rate in the U.S., 143 prescriptions are written for every 100 people.31



Financial cost of opioid addiction tops $193 billion annually


Addiction to opioids and heroin now costs the U.S. more than $193 billion each year.



Prenatal exposure is rampant


Despite carrying risks of pregnancy-related problems and birth defects, nearly one-third of American women of childbearing age are prescribed opioid painkillers32 and more than 14 percent of pregnant women were prescribed opioids during their pregnancy.33



Addiction affects more than 1 in 4 opioid users


Studies show addiction affects about 26 percent of those using opioids for chronic non-cancer pain, and 1 in 550 patients on opioid therapy die from opioid-related causes within 2.5 years of their first prescription.34



Opioid addiction has lowered life expectancy in U.S.


According to the latest data from the National Center for Health Statistics, life expectancy for both men and women dropped between 2014 and 2015, for the first time in two decades, and overdose deaths appear to be a significant contributor.35,36,37



Prescription painkillers are the No. 1 gateway to heroin


OxyContin and other opioid pain killers have been identified as the primary gateway drugs to heroin.38 Chemically, these drugs are very similar and provide a similar kind of high. According to a 2013 U.S. Substance Abuse and Mental Health Services Administration report, nearly 80 percent of people who use heroin have previously used prescription painkillers.39



Opioid use and addiction found to have lifelong health ramifications


According to Dr. Scott Krakower, assistant unit chief for psychiatry at Zucker Hillside Hospital in New York, opioids cause changes in your brain that can increase your risk of depression, and the effects may be “long-lasting or even permanent.”40


Opiates depress your central nervous system and slow the electrical activity in your brain, which can result in circadian rhythm disruptions, mood changes and cognitive decline. Opiate use also promotes41 bowel dysfunction, endocrine system (hormonal) problems, sexual dysfunction, reduced fertility, reduced testosterone levels in men and bone disorders.


Drug Industry Responsible for Mass Addiction Now Tries to Cash in on It


Many believe the drug companies that create and sell opioids need to be held accountable for America’s drug problem, especially since several have been caught lying about the benefits and risks of their drugs. As noted by the Organic Consumers Association,42 the drug industry has “fostered the opioid addiction epidemic” by:


  • Introducing long-acting opioid painkillers like OxyContin, which from a chemical standpoint is nearly identical to heroin, and changing pain prescription guidelines to make opioids the first choice for lower back pain and other pain conditions that previously did not qualify for these types of drugs.

  • Promoting long-term use of opioids even though there’s no evidence that using these drugs long-term is safe and effective, and grossly downplaying their addictive potential. OxyContin, for example, became a blockbuster drug mainly through misleading claims that Purdue Pharma knew were false from the start.43

Now, adding insult to injury, drug companies are trying to cash in on the opioid addiction crisis by pushing for legislation to combat the epidemic with, you guessed it, other drugs. NPR recently reported how Alkermes, a company that makes the anti-addiction medication Vivitrol — a monthly injection that costs about $1,000 per shot — is trying to weasel its drug into state laws, making it the sole treatment recommended for opioid addiction. NPR writes:44



“Two years ago, a mental health advocate named Steve McCaffrey stood at a podium in the Indiana statehouse, testifying in favor of an addiction treatment bill … His brief testimony appeared straightforward. ‘We rise in support, urge your adoption,’ said McCaffrey. He said the legislation would move the state ‘toward evidence-based treatment.’ But the bill wouldn’t do that.




Instead, it would cement rules making it harder to access certain addiction medications — medications that many patients rely on. The goal was to steer doctors toward a specific brand-name drug: Vivitrol … State Rep. Steve Davisson, the bill’s sponsor, says McCaffrey helped write the bill … But there was something important that Davisson and other lawmakers didn’t know about him.




State lobbying records show that McCaffrey lobbies for Alkermes, the company that makes Vivitrol …  McCaffrey’s work … is part of a larger pattern … [I]n statehouses across the country, and in Congress, Alkermes is pushing Vivitrol while contributing to misconceptions and stigma about other medications used to treat opioid addiction …




While policymakers are grasping for solutions to the nation’s opioid epidemic, Alkermes … is using policy to promote its drug and, in some cases, hamper access to medications that can help. And in so doing, it’s looking to turn its drug into a blockbuster.”



Industry Regulations Hamper Legal Recourse


A growing number of U.S. states,45 counties and even individual cities have filed lawsuits against opioid manufacturers for their role in creating the addiction crisis. Unfortunately, it’s proving to be extremely difficult to hold drug companies accountable for their actions. As reported by Reuters,46 “The industry’s highly regulated nature could pose a hurdle to their success.” Since opioids, like all drugs, are regulated by the U.S. Food and Drug Administration (FDA), drug companies simply lean on the drugs’ FDA approval.



“In their view, judges and juries could defer to the agency’s approval of the companies’ opioid products as safe and effective for treating chronic pain and of the drugs’ warning labels that disclosed addiction-related risks,” Reuters notes.




“Carl Tobias, a professor at Richmond School of Law, said FDA-approved warning labels and the role of doctors in prescribing medication can insulate pharmaceutical companies from liability for failing to warn of a drug’s risks. But he noted Ohio’s lawsuit claimed the companies used advertising in medical journals and marketing presentations to downplay the risks of opioids.




In announcing the lawsuit, Ohio Attorney General [Mike] DeWine argued the drugmakers’ deception continued ‘despite the warnings in the small print of their very own drug labels and package inserts which clearly contradict their marketing.’ ‘You can give a great warning but undercut it, and that can go to the fraud point,’ Tobias said.”



Drug companies are also arguing that state and local governments should not be allowed to use private lawyers when filing these kinds of lawsuits against them. Private attorneys typically receive a percentage of the settlement, and drug companies have argued that hiring private lawyers rather than using public servants violates their constitutional rights to due process. This ridiculous argument has already worked once.


Last year, a judge invalidated the law firm Cohen Milstein Sellers & Toll’s agreement to represent former New Hampshire Attorney General Joseph Foster in his lawsuit against Actavis Pharma, Endo Pharmaceuticals, Janssen Pharmaceuticals, Purdue Pharma and Teva Pharmaceuticals.47 The ruling effectively prevented the state from filing suit, since no “public servants” with the prerequisite legal skills are available to run the case.


Are You or Someone You Love Addicted to Painkillers?



This is a Flash-based audio and may not be playable on mobile devices.


Anyone can get hooked on opioids. It doesn’t matter where you live or how great a family you came from. STAT News’ special report, “52 Weeks, 52 Faces” features obituaries of people who lost their lives to opioid addiction. You’d be hard-pressed to “peg” any one of them as a drug addict.


Some marketing materials for opioids still claim the drug will not cause addiction “except in very rare cases,” describing the adverse effects patients experience when quitting the drug as a “benign state” and not a sign of addiction. This simply isn’t true. Panic is one psychological side effect commonly experienced when quitting these drugs, and this can easily fuel a psychological as well as physical dependence on the drug.


It’s important to recognize the signs of addiction, and to seek help. If you’ve been on an opioid for more than two months, or if you find yourself taking higher dosages, or taking the drug more often, you’re likely already addicted and are advised to seek help from someone other than your prescribing doctor. Resources where you can find help include:


With all the health risks associated with opioid painkillers, I strongly urge you to exhaust other options before resorting to these drugs. For a long list of alternative pain treatments, please see my previous articles, “Treating Pain Without Drugs,” and “New Treatment Guidelines for Back Pain Stress Non-Drug Interventions.”

How Misuse of a Single Paragraph Ended Up Killing 60,000 Americans Per Year

How Misuse of a Single Paragraph Ended Up Killing 60,000 Americans Per Year | writing | Big Pharma General Health Medical & Health Sleuth Journal Special Interests US News



Opioid addiction is at an all-time high in the U.S., and according to many addiction specialists, pain and hopelessness are primary drivers of this burgeoning crisis.1 Limiting the availability of opioids and making overdose-reversal drugs and treatment for drug addiction more readily available are part of the answer. But it’s not enough.


We have to take a much deeper look at the root of the problem. What is causing all this physical pain and emotional distress in the first place? Clearly, the U.S. health care system is grossly ineffective when it comes to addressing chronic health problems. Whether pain is promoting hopelessness or the other way around is difficult to ascertain, but the two appear to be closely intertwined and need to be addressed together.



Somehow or another, we need to refocus our efforts to create lives worth living, and improve access to and information about basic disease prevention, which begins with diet and basic lifestyle choices — the kind of information I’ve focused on with my newsletter and website.


That said, it’s worth looking at how use of prescription opioids ended up getting so out of control. Doing so will reveal an oft-ignored truth: Drug companies may, and often do, promote drugs that do more harm than good. After all, drugs are profit centers, and drug companies are first and foremost beholden to their shareholders — not patients — who expect to make a decent profit from their investments.


To maximize sales, drug companies may hide information, misinform and/or outright lie about their medicines, and this is precisely what happened with narcotic painkillers.


The Paragraph That Spawned the Opioid Crisis


In 1980, a five-sentence-long letter to the editor was published in the New England Journal of Medicine (NEJM), one of the most prestigious medical journals in the world. Under the headline “Addiction Rare in Patients Treated With Narcotics,” the short letter, written by Jane Porter, a graduate student at Boston University Medical Center, read:



“Recently, we examined our current files to determine the incidence of narcotic addiction in 39,946 hospitalized medical patients who were monitored consecutively. Although there were 11,882 patients who received at least one narcotic preparation, there were only four cases of reasonably well documented addiction in patients who had no history of addiction.




The addiction was considered major in only one instance. The drugs implicated were meperidine in two patients, Percodan in one, and hydromorphone in one. We conclude that despite widespread use of narcotic drugs in hospitals, the development of addiction is rare in medical patients with no history of addiction.”



This turned out to be a letter with dire repercussions for millions of people in the decades to come. As noted in The Atlantic, this letter to the editor ended up being “so routinely mis-cited” it took on “a life of its own.”2



“[NEJM] … is issuing a corrective. It’s a new study3 … from a team led by David Juurlink at the University of Toronto that tracked how the five-sentence letter passed through the game of academic citation … to become evidence that opioids are safe for chronic pain. In fact, it said no such thing,” The Atlantic notes.




“… Hershel Jick, a doctor at Boston University Medical Center, had a database of hospital records that he used to monitor side effects from drugs … Something, perhaps a newspaper article, got Jick interested in looking at addiction. So he asked a graduate student, Jane Porter, to help calculate how many patients in the database got addicted after being treated with pain medicines, and dashed off a letter to the [NEJM].




Its brevity was commensurate with the effort involved … But as it began to accrue citations, its findings also began to mutate. Porter and Jick had only looked at hospitalized patients in regimented settings, but that detail got lost in the push to prescribe opioids to patients at home — an entirely different scenario.”



Drug Companies Latched on to Evidence That Wasn’t


In the years to come, this letter to the editor (most letters do not undergo any kind of peer-review) became an oft-cited piece of evidence used by drug companies and pain specialists alike. In all, it’s been cited more than 600 times since its publication, serving as the basis of misleading and inaccurate statements such as: “[P]ain population with no abuse history is literally at no risk for addiction,” and “There have been studies suggesting that addiction rarely evolves in the setting of painful conditions.”4


A remarkable 80 percent of the articles citing Jick’s letter failed to include the facts that his data pertained specifically to hospitalized patients receiving the drugs on a short-term basis. You simply cannot assume that because a narcotic is safe to use in the short term under careful monitoring by hospital staff, it will be safe long-term, and without careful monitoring.


According to Juurlink, “It’s difficult to overstate the role of this letter. It was the key bit of literature that helped the opiate manufacturers convince front-line doctors that addiction is not a concern.”5


Purdue Pharma used it as the basis for its claim that opioid addiction affects less than 1 percent of patients treated with the drugs. In a recent interview with The Associated Press (AP),6 Jick said he was “mortified that that letter to the editor was used as an excuse to do what these drug companies did.” He also clarified that his letter “only referred to people getting opioids in the hospital for a short period of time and has no bearing on long-term outpatient use.”


Researchers and journalists were no better. While the findings detailed in the letter were exceptionally narrow and the “study” less than thorough, researchers and journalists started referring to it as “extensive,” citing it as a “landmark report.” In 2001, Time magazine reported:7



“Many physicians now concede that patients have been undermedicated for decades, suffering needlessly. One reason was concern that big doses of opiates could depress respiration, but a large part stemmed from an exaggerated fear that patients would become addicted.




This fear, which continues to hold sway over American medicine, is basically unwarranted. A landmark study … found that only four became addicted to the [narcotic] drugs they received as patients. ‘You don’t see cancer patients running around robbing shopping malls to support their habits,’ notes Carr.”



NEJM Issues First-Ever Warning on 40-Year-Old Editor’s Note


Following the publication of Juurlink’s investigation into the citation trail leading from Jick’s letter to all manner of false claims, NEJM has now added an editor’s note to the 1980 letter,8 saying, “For reasons of public health, readers should be aware that this letter has been ‘heavily and uncritically cited’ as evidence that addiction is rare with opioid therapy.”


NEJM editor, Dr. Jeffrey Drazen, explained his note to AP, saying, “People have used the letter to suggest that you’re not going to get addicted to opioids if you get them in a hospital setting. We know that not to be true.”9 The journal has also added a link from Jick’s letter to Juurlink’s new study — a move that should eliminate most misuse in the future. As noted by Juurlink:10



“In conclusion, we found that a five-sentence letter … was heavily and uncritically cited as evidence that addiction was rare with long-term opioid therapy. We believe that this citation pattern contributed to the North American opioid crisis by helping to shape a narrative that allayed prescribers’ concerns about the risk of addiction associated with long-term opioid therapy.




In 2007, the manufacturer of OxyContin and three senior executives pleaded guilty to federal criminal charges that they misled regulators, doctors and patients about the risk of addiction associated with the drug. Our findings highlight the potential consequences of inaccurate citation and underscore the need for diligence when citing previously published studies.”



60,000 Americans Overdosed in 2016


Opioid addiction and accidental overdoses are now taking a tremendous toll. According to U.S. Deputy Attorney General Rod Rosenstein, drug overdoses are now the leading cause of death among Americans under the age of 50!11 In 2015, more than 52,000 Americans died from some form of drug overdose; 33,000 of them involved some form of opioid.


Preliminary data for 2016 reveals that death toll is anywhere from 59,000 to 65,000.12 That’s a 19 percent increase in one year, and the largest annual increase of drug overdose deaths in U.S. history. Between 2014 and 2015, drug overdose deaths rose by 11 percent.13The most common drugs involved in prescription opioid overdose deaths include14 methadone, oxycodone (such as OxyContin®) and hydrocodone (such as Vicodin®).


Synthetic opioids like fentanyl are also being abused by a rising number of people. A recent article in The New York Times15 highlights the tragedy of Grant Seaver and Ryan Ainsworth, two 13-year-olds who died after taking the synthetic opioid U-47700, also known as “pinky.” They got the drug from a teenage friend who had bought it on the dark web using bitcoin.


The sheer potency of synthetic opioids make them ideal for mailing. A standard envelope can hold enough fentanyl to get 50,000 people high. And, while the dark web marketplace Silk Road was shut down in 2013, others have popped up in its place, allowing people who might otherwise not have access to narcotics get them through the mail.


Disturbingly, rising fentanyl addiction also poses novel risks to first responders, law enforcement and even drug-sniffing dogs. The drug is so potent (anywhere from 500 to 1,000 percent more potent than morphine) that inhaling just a few flakes can be lethal.


In Ohio, a police officer nearly died from exposure to a fentanyl-related compound. During a routine traffic stop, he noticed a bag of white powder in the car. He used gloves and a mask for protection at the scene, but didn’t notice he’d gotten some on his shirt. Later, when a colleague pointed out the powder on his uniform, he brushed it off with his bare hand.


An hour later, he collapsed and had to be treated with FOUR doses of naloxone. He was lucky and survived the ordeal. Many fentanyl users are not. Deadly overdoses involving fentanyl rose by 50 percent between 2013 and 2014, and another 72 percent between 2014 and 2015.


Other Opioid Facts and Statistics


To truly understand the enormity of America’s drug problem, consider the following:














Drug overdoses are the ninth leading cause of death in the U.S.


In 2015, 52,404 Americans died from drug overdoses; 33,091 of them involved an opioid and nearly one-third of them, 15,281, of them were by prescription.16,17,18 Meanwhile, kidney disease, listed as the ninth leading cause of death on the CDC’s top 10 list, killed 48,146.19


The CDC does not include drug overdoses on this list, but if you did, drug overdoses (63 percent of which are opioids), would replace kidney disease as the ninth leading cause of death as of 2015, inching its way toward the eighth slot, currently occupied by respiratory complications such as pneumonia, which took 55,227 lives in 2015. As noted earlier, in the 50-and-younger demographic, drug overdoses are now the No. 1 cause of death.20



Opioid use has overtaken smoking


More Americans now use prescription opioids than smoke cigarettes.21 One in 4 Americans (and 1 in 3 millennials) reports knowing someone addicted to opioids.22



Opioids kill more Americans than car crashes


In 2014, prescription drug overdoses, a majority of which involved some type of opioid, killed more Americans than car crashes (49,714 compared to 32,675).23 This held true for 2015 as well, despite 2015 being hailed as the deadliest driving year since 2008. In all, 38,300 Americans died in car crashes in 201524 — a sharp rise thought to be related to a combination of cheaper gas prices and hence increased travel, and using smartphones while driving.25



Drugged driving causes more fatal crashes than drunk driving


Driving under the influence of opioids and other drugs has become a serious problem, now causing more fatal car crashes than drunk driving.26 Prescription and/or illegal drugs were involved in 43 percent of fatal car crashes in 2015, while 37 percent involved illegal amounts of alcohol.


Opioids, specifically, can increase your risk of being involved in a car crash by a factor of 10, having a relative car crash risk between 2 and 10.27 (A driver with no drugs or alcohol in their system has a relative crash risk of 1.)



Americans use 80 percent of global opioid supply


Prescriptions for opioid painkillers rose by 300 percent between 2000 and 2009,28,29 and Americans now use 80 percent of all the opioids sold worldwide.30 In Alabama, which has the highest opioid prescription rate in the U.S., 143 prescriptions are written for every 100 people.31



Financial cost of opioid addiction tops $193 billion annually


Addiction to opioids and heroin now costs the U.S. more than $193 billion each year.



Prenatal exposure is rampant


Despite carrying risks of pregnancy-related problems and birth defects, nearly one-third of American women of childbearing age are prescribed opioid painkillers32 and more than 14 percent of pregnant women were prescribed opioids during their pregnancy.33



Addiction affects more than 1 in 4 opioid users


Studies show addiction affects about 26 percent of those using opioids for chronic non-cancer pain, and 1 in 550 patients on opioid therapy die from opioid-related causes within 2.5 years of their first prescription.34



Opioid addiction has lowered life expectancy in U.S.


According to the latest data from the National Center for Health Statistics, life expectancy for both men and women dropped between 2014 and 2015, for the first time in two decades, and overdose deaths appear to be a significant contributor.35,36,37



Prescription painkillers are the No. 1 gateway to heroin


OxyContin and other opioid pain killers have been identified as the primary gateway drugs to heroin.38 Chemically, these drugs are very similar and provide a similar kind of high. According to a 2013 U.S. Substance Abuse and Mental Health Services Administration report, nearly 80 percent of people who use heroin have previously used prescription painkillers.39



Opioid use and addiction found to have lifelong health ramifications


According to Dr. Scott Krakower, assistant unit chief for psychiatry at Zucker Hillside Hospital in New York, opioids cause changes in your brain that can increase your risk of depression, and the effects may be “long-lasting or even permanent.”40


Opiates depress your central nervous system and slow the electrical activity in your brain, which can result in circadian rhythm disruptions, mood changes and cognitive decline. Opiate use also promotes41 bowel dysfunction, endocrine system (hormonal) problems, sexual dysfunction, reduced fertility, reduced testosterone levels in men and bone disorders.


Drug Industry Responsible for Mass Addiction Now Tries to Cash in on It


Many believe the drug companies that create and sell opioids need to be held accountable for America’s drug problem, especially since several have been caught lying about the benefits and risks of their drugs. As noted by the Organic Consumers Association,42 the drug industry has “fostered the opioid addiction epidemic” by:


  • Introducing long-acting opioid painkillers like OxyContin, which from a chemical standpoint is nearly identical to heroin, and changing pain prescription guidelines to make opioids the first choice for lower back pain and other pain conditions that previously did not qualify for these types of drugs.

  • Promoting long-term use of opioids even though there’s no evidence that using these drugs long-term is safe and effective, and grossly downplaying their addictive potential. OxyContin, for example, became a blockbuster drug mainly through misleading claims that Purdue Pharma knew were false from the start.43

Now, adding insult to injury, drug companies are trying to cash in on the opioid addiction crisis by pushing for legislation to combat the epidemic with, you guessed it, other drugs. NPR recently reported how Alkermes, a company that makes the anti-addiction medication Vivitrol — a monthly injection that costs about $1,000 per shot — is trying to weasel its drug into state laws, making it the sole treatment recommended for opioid addiction. NPR writes:44



“Two years ago, a mental health advocate named Steve McCaffrey stood at a podium in the Indiana statehouse, testifying in favor of an addiction treatment bill … His brief testimony appeared straightforward. ‘We rise in support, urge your adoption,’ said McCaffrey. He said the legislation would move the state ‘toward evidence-based treatment.’ But the bill wouldn’t do that.




Instead, it would cement rules making it harder to access certain addiction medications — medications that many patients rely on. The goal was to steer doctors toward a specific brand-name drug: Vivitrol … State Rep. Steve Davisson, the bill’s sponsor, says McCaffrey helped write the bill … But there was something important that Davisson and other lawmakers didn’t know about him.




State lobbying records show that McCaffrey lobbies for Alkermes, the company that makes Vivitrol …  McCaffrey’s work … is part of a larger pattern … [I]n statehouses across the country, and in Congress, Alkermes is pushing Vivitrol while contributing to misconceptions and stigma about other medications used to treat opioid addiction …




While policymakers are grasping for solutions to the nation’s opioid epidemic, Alkermes … is using policy to promote its drug and, in some cases, hamper access to medications that can help. And in so doing, it’s looking to turn its drug into a blockbuster.”



Industry Regulations Hamper Legal Recourse


A growing number of U.S. states,45 counties and even individual cities have filed lawsuits against opioid manufacturers for their role in creating the addiction crisis. Unfortunately, it’s proving to be extremely difficult to hold drug companies accountable for their actions. As reported by Reuters,46 “The industry’s highly regulated nature could pose a hurdle to their success.” Since opioids, like all drugs, are regulated by the U.S. Food and Drug Administration (FDA), drug companies simply lean on the drugs’ FDA approval.



“In their view, judges and juries could defer to the agency’s approval of the companies’ opioid products as safe and effective for treating chronic pain and of the drugs’ warning labels that disclosed addiction-related risks,” Reuters notes.




“Carl Tobias, a professor at Richmond School of Law, said FDA-approved warning labels and the role of doctors in prescribing medication can insulate pharmaceutical companies from liability for failing to warn of a drug’s risks. But he noted Ohio’s lawsuit claimed the companies used advertising in medical journals and marketing presentations to downplay the risks of opioids.




In announcing the lawsuit, Ohio Attorney General [Mike] DeWine argued the drugmakers’ deception continued ‘despite the warnings in the small print of their very own drug labels and package inserts which clearly contradict their marketing.’ ‘You can give a great warning but undercut it, and that can go to the fraud point,’ Tobias said.”



Drug companies are also arguing that state and local governments should not be allowed to use private lawyers when filing these kinds of lawsuits against them. Private attorneys typically receive a percentage of the settlement, and drug companies have argued that hiring private lawyers rather than using public servants violates their constitutional rights to due process. This ridiculous argument has already worked once.


Last year, a judge invalidated the law firm Cohen Milstein Sellers & Toll’s agreement to represent former New Hampshire Attorney General Joseph Foster in his lawsuit against Actavis Pharma, Endo Pharmaceuticals, Janssen Pharmaceuticals, Purdue Pharma and Teva Pharmaceuticals.47 The ruling effectively prevented the state from filing suit, since no “public servants” with the prerequisite legal skills are available to run the case.


Are You or Someone You Love Addicted to Painkillers?



This is a Flash-based audio and may not be playable on mobile devices.


Anyone can get hooked on opioids. It doesn’t matter where you live or how great a family you came from. STAT News’ special report, “52 Weeks, 52 Faces” features obituaries of people who lost their lives to opioid addiction. You’d be hard-pressed to “peg” any one of them as a drug addict.


Some marketing materials for opioids still claim the drug will not cause addiction “except in very rare cases,” describing the adverse effects patients experience when quitting the drug as a “benign state” and not a sign of addiction. This simply isn’t true. Panic is one psychological side effect commonly experienced when quitting these drugs, and this can easily fuel a psychological as well as physical dependence on the drug.


It’s important to recognize the signs of addiction, and to seek help. If you’ve been on an opioid for more than two months, or if you find yourself taking higher dosages, or taking the drug more often, you’re likely already addicted and are advised to seek help from someone other than your prescribing doctor. Resources where you can find help include:


With all the health risks associated with opioid painkillers, I strongly urge you to exhaust other options before resorting to these drugs. For a long list of alternative pain treatments, please see my previous articles, “Treating Pain Without Drugs,” and “New Treatment Guidelines for Back Pain Stress Non-Drug Interventions.”

Thursday, June 1, 2017

Ohio Sets Major Precedent, Sues Big Pharma for Deliberately ‘Fueling Opioid Epidemic’

opioid



Five goliath pharmaceutical companies have been served with a lawsuit from the State of Ohio for their role in the opioid epidemic, because, as state Attorney General Mike DeWine alleges, they “helped unleash a health care crisis that has had far-reaching financial, social, and deadly consequences in the State of Ohio.”


Ohio now joins a number of states in attempting to hold Big Pharma responsible for fueling the crisis of oft-ruinous addiction to legally prescribed opioid medications and their deemed illegal brethren, such as heroin.


Purdue Pharma, Endo Health Solutions, Teva Pharmaceutical Industries and its subsidiary, Cephalon, Johnson & Johnson and subsidiary, Janssen Pharmaceuticals, and Allergan have all been named in the lawsuit.


“This lawsuit is about justice, it’s about fairness, it’s about what is right,” DeWine opined in an announcement from southern Ohio’s Ross County — an area crushed by the epidemic in fatalities from overdoses to legal painkillers and illegal heroin — as quoted by Southwestern Ohio NBC affiliate, WLWT. “These drug companies knew that what they were saying was wrong and they did it anyway and they continue to do so.”


Figures for 2016, which have yet to be released, are expected to handily top the distressing 3,050 fatal overdoses Ohio experienced in 2015 — figures wholly unacceptable to DeWine, and cogent of the nation’s struggle to rein in rampant over-prescribing and other facets of the opioid scourge.


NPR reports the lawsuit “accuses the companies of engaging in a sustained marketing campaign to downplay the addiction risks of the prescription opioid drugs they sell and to exaggerate the benefits of their use for health problems such as chronic pain.”


“We believe the evidence will also show that these companies got thousands and thousands of Ohioans — our friends, our family members, our co-workers, our kids — addicted to opioid pain medications, which has all too often led to use of the cheaper alternatives of heroin and synthetic opioids,” the Ohio attorney general asserted in a press release excoriating the five pharmaceutical companies Wednesday. “These drug manufacturers led prescribers to believe that opioids were not addictive, that addiction was an easy thing to overcome, or that addiction could actually be treated by taking even more opioids.


“They knew they were wrong, but they did it anyway — and they continue to do it.  Despite all evidence to the contrary about the addictive nature of these pain medications, they are doing precious little to take responsibility for their actions and to tell the public the truth.”


Explicitly, DeWine notes, the lawsuit contends the medications at the core of the epidemic include OxyContin, MS Contin, Dilaudid, Butrans, Hysingla, and Targiniq from Purdue; Endo’s Percocet, Percodan, Opana, and Zydone; Actiq and Fentora made by Teva and Cephalon; Johnson & Johnson and Janssen’s Duragesic and Nucynta; and Kadian, Norco, and several generic opioids manufactured by Allergan.



DeWine told NPR’s All Things Considered the companies purposely deceived physicians and medical practitioners on the perils of the opioid medications — purely to rake in profits — to the horrific detriment of thousands of families whose loved ones became addicted or lost their lives.


“We believe that the evidence will show that these pharmaceutical companies purposely misled doctors about the dangers connected with pain meds that they produced, and that they did so for the purpose of increasing sales,” he asserted. “And boy, did they increase sales.”


“My daughter’s been gone over a year and it still doesn’t seem real,” Ohio father Roger Winemiller, whose daughter and son died within nine months of each other — both from overdoses on heroin — told WLWT.


Echoing one of the most common paths to illegal heroin, Winemiller described the lost battle with addiction his daughter faced, recalling that, to treat anxiety, she “started using pills and tried stuff that the doctor prescribed but it just didn’t work, then went to pills on the street then graduated to heroin.”


Included in the state’s lawsuit is an injunction demanding the companies cease deceptive practices — inflation of benefit and deflation of risks — surrounding opioid prescriptions.


Rather than pegging doctors equally responsible the opioid plague, DeWine told NPR’s Robert Siegel the weight of blame lies with the mendacious practices consciously undertaken by the five Big Pharma giants and their subsidiaries.


“This was not something that the pharmaceutical companies just woke up some day and just started to do a little bit of it,” the attorney general explained.


“I mean, there was a concerted effort for an extended number of years to really pound this into the heads of doctors. And when you’re told something time and time and time again and there’s a lot of advertising that is being spent, yeah, it takes a while to turn that around.”



Naturally, Big Pharma pushed back against the lawsuit — a spokeswoman for Janssen castigated the premise as “legally and factually unfounded.”


“Janssen has acted appropriately, responsibly and in the best interests of patients regarding our opioid pain medications,” Jessica Castles Smith told the Cleveland Plain Dealer by email, “which are FDA-approved and carry FDA-mandated warnings about the known risks of the medications on every product label.”


Purdue, however, appeared to capitulate somewhat — agreeing the epidemic must be addressed.


“OxyContin accounts for less than 2 percent of the opioid analgesic prescription market nationally,” the company told the Plain Dealer, “but we are an industry leader in the development of abuse-deterrent technology, advocating for the use of prescription drug monitoring programs and supporting access to Naloxone — all important components for combating the opioid crisis.”


NPR noted the state estimates more than 200,000 Ohioans currently battle addiction to opioids.


DeWine elaborated further, telling the Plain Dealer 80 percent of heroin addicts first were prescribed legal opioid medications — and that, although this particular lawsuit aims to hold manufacturers accountable, he refused to rule out future litigation against distributors.


Opioids continue to be doled out with alarming regularity for both acute and chronic pain, while viable alternatives to both treat pain and reduce opioid dependency — such as cannabis and kratom — remain unattainable thanks to the Federal Government’s laughable war on drugs.


In the meantime, a growing number of states and localities — including Everett, Washington, and the states of West Virginia, Mississippi, and Kentucky — as well as the Cherokee Nation, have employed legal means to call Big Pharma to task for recklessly allowing the opioid crisis to fester unhindered.


“It’s not the whole cause, but it’s a big part of the cause,” Winemiller said of the targets of the lawsuit. “I mean, there’s many, many people that’s gone to pain clinics, had surgeries or whatever, and they take this medication and they get hooked on it, and then they get cut off and so they go the cheaper route and end up with the heroin.”



He added, “I’ve lost two [children]. It’s just like a bad dream that won’t quit.”

Monday, May 22, 2017

10 Music Legends Who Were Killed By Big Pharma and the War On Drugs

drug



“Chris’s death is a loss that escapes words and has created an emptiness in my heart that will never be filled,” Vicky Cornell, wife of late Soundgarden and Audioslave musician, Chris Cornell, lamented in a statement. “As everyone who knew him commented, Chris was a devoted father and husband. He was my best friend.”


Vicky, reverently recalling Chris’ time spent with their children over Mother’s Day and plans for a Memorial Day vacation, expressed pain and grief in that Friday morning announcement following his death in the wee hours Thursday morning.


But she also suggested a pharmaceutical frequently prescribed to combat addiction played a role in the rocker’s death — Ativan, a benzodiazepine similar to Valium or Xanax, came up in Vicky’s last conversation with Cornell.


“When we spoke after the show, I noticed he was slurring his words; he was different,” she continued, as quoted by Rolling Stone. “When he told me he may have taken an extra Ativan or two, I contacted security and asked that they check on him.”


Attorney Kirk Pasich elucidated further, stating, “Without the results of toxicology tests, we do not know what was going on with Chris — or if any substances contributed to his demise. Chris, a recovering addict, had a prescription for Ativan and may have taken more Ativan than recommended dosages. The family believes that if Chris took his life, he did not know what he was doing, and that drugs or other substances may have affected his actions.”


That Chris Cornell indeed actively sought to curtail a notorious drug dependency with the aid of a physician — who unfortunately then prescribed legal medication as pernicious as substances the State deems illicit — underscores the inanity of the U.S. government’s dangerous drug war.


Schizophrenic drug policy makes criminals of addicts, users, and dealers, without providing options for those genuinely seeking radical change in treatment. Those who avoid the injustice system or finish time served and want help do not always fare well.


Standard medical practice frequently toes the drug war’s blurry line, as doctors dole out benzodiazepines and other prescribable drugs deemed ‘medications,’ whose side effects can mimic and mirror the most undesirable symptoms of the original subject of addiction — or worse.


Ativan, as many of these legal medications — and mimicking full-fledged addiction — warns in its laundry list of side effects to notify a doctor if the user experiences “thoughts of suicide or hurting yourself” and “unusual changes in mood or behavior.”


Now, reread both the attorney’s and Vicky Cornell’s statements on Chris’ behavior. Is this truly the optimum method to fight the epidemic of addiction and overdose science can manage?


For the duration of the failed war on drugs, the answer remains a decisive — wholly unnecessary — ‘yes.’


And appallingly so, given the State would only need lift prohibition on cannabis to truncate the spiraling opioid epidemic — an incendiary time bomb fueled by excessive prescribing of legal opioid prescriptions and worsened by the availability of cheap, but oft-tainted, illegal opiates flooding the country.


This multifaceted mess — which, whatever the medical examiner determines, ultimately took Chris Cornell’s life — has left a trail of bodies for decades, plucking icons of the music world as readily as your next door neighbor, in a politicized phantasm of calamity worthy only the U.S. Empire of Lies.


Following are just nine other musicians who ran headlong into the drug war whose only success is the misery of its incarcerated and suffering victims — including those erased too early, more for illegality and impotent solutions, rather than the substances, themselves.



Billie Holiday



READ MORE:  Gang of Thieves: DEA Stole $3.2 Billion in Cash From Innocent People in Only a Decade



Original drug warrior, himself, Harry Anslinger, revived failed alcohol prohibition through a facelift and refocusing of subject matter — without bathtub bootleggers to ruin, he spearheaded the effort to destroy pot smokers and dealers — and the entirety of the jazz movement.


Appointed head of the nascent Federal Bureau of Narcotics in 1930, Anslinger ultimately tried in vain to root out a network of drug users and dealers he saw responsible for the free-form jazz so cacophonous to his ears. Holiday, to him, represented an archetypal African American jazz musician, loosened in morals and apparently threatening to some mythical — and quite lily white — law and order.


With a horrendous addiction to drugs and alcohol already numbing Holiday’s emotional and physical pain, Louis McKay — her husband, punishingly abusive manager, and sometimes pimp — worked with Anslinger to set her up for prison, and teach the jazz world a lesson that it wasn’t beyond the arm of law.


Successful the first time, sending her to prison for a year, Anslinger’s second attempt robbed the planet of jazz virtuoso — but her melodic notes and keenness to the drug war’s bloodthirsty underbelly lives on. Rather than blame law enforcement agents as individuals, Holiday had the wherewithal to instead lay blame for her heroin addiction where it rightfully belonged: the war on drugs, itself.


“Imagine if the government chased sick people with diabetes, put a tax on insulin and drove it into the black market, told doctors they couldn’t treat them,” Holiday penned in a damning memoir, quoted by journalist, expert, and ex-addict, Johann Hari, “then sent them to jail. If we did that, everyone would know we were crazy. Yet we do practically the same thing every day in the week to sick people hooked on drugs.”


Prince


In April 2016, the epochal and revolutionary singer Prince succumbed to an accidental overdose of counterfeit fentanyl — a faster-acting, synthetic, and immensely stronger legal painkiller than even the hydro- or oxycodone so commonly prescribed in the U.S. Although the 57-year-old icon had not been given a doctor’s order for any controlled substances in his home state of Minnesota over the preceding 12 months, at least 20 bottles of vitamins and prescriptions tested positive for the dangerous substance and others.


Fentanyl can be every bit as addictive as heroin — and, being legal but often prescribed on a limited basis, the painkiller kills more than pain — with black market counterparts frequently containing unwanted or unannounced additives, perilous in their own right.


Whether or not Prince harbored a surreptitious fentanyl habit may never be known — but responsibility for his death can be veritably thrown at the drug war’s feet. Had the prodigious vocalist and instrumentalist sought and obtained fentanyl from a legal market — where quality control would be key, without arbitrary illegality of the war on drugs — it’s likely an imposter product would not have stolen his last breath.


Scott Weiland



READ MORE:  Woman Publicly Raped in Gas Station Parking Lot by Cops Because they "Smelled Weed"



Just one week after Thanksgiving, Stone Temple Pilots and Velvet Revolver frontman, Scott Weiland, fatally overdosed on a toxic mix of illicit and legal substances, over a decade after ending a public chronicle of addiction. What fans had not been privy to was Weiland’s private torment — bipolar disorder — of which wife, Jamie, who met the singer in 2011 and swiftly understood the monster, recalled for Billboard last year,


“He would be on the couch with a drink, smoking and watching whatever mindless television. I started to see he had ­paranoia and some of the bipolar stuff started to come out.”


Keeping all curtains drawn and acting increasingly unhinged, Weiland forced Jamie into an allegorical corner — and she vacated their home in self-preservation, on at least one occasion.


An effective prescription seemed to treat his symptoms, but side effects like untenable weight gain led Weiland to dump the promising palliative — and try, drop, and uptake a number of others, alongside the heroin and alcohol which strangled the vocalist’s reason and rationale.


“The Hennepin County Medical Examiner’s Office released a ­statement on Dec. 18,” Billboard reported, “finding that Weiland died ­accidentally of mixed-drug toxicity: cocaine, ethanol and ­methylenedioxyamphetamine (an analog of MDMA). Other ­significant conditions noted were ­atherosclerosis, cardiovascular ­disease, asthma and ­multiple-substance ­dependence. Plus, he was on prescription medications Lunesta, Klonopin, Viagra, Dalmane, Buprenex and Geodon.”


Without extenuating potential legal ramifications surrounding the illicit drugs, or a national imperative to insert addicts in treatment programs rather than cages, perhaps Weiland — who had sought costly assistance on multiple occasions — might have escaped with his life.


Jimi Hendrix


“Hailed by Rolling Stone as the greatest guitarist of all time,” the magazine notes in a biographical page devoted to the legend, “Jimi Hendrix was also one of the biggest cultural figures of the Sixties, a psychedelic voodoo child who spewed clouds of distortion and pot smoke.”


Given the phenom’s breadth of talent and sheer audacity, perhaps no description of Hendrix’ life and accomplishments would ever sufficiently summarize his legendary status around the globe. But fame being the nefarious punisher, Hendrix ultimately fell victim to a spectrum of legal and illicit substances at just 27 years of age, albeit almost certainly by accident.


On the day following the death of the world’s musical idol, September 19, 1970, journalist Henry Maule wrote for the Daily News Hendrix “was found deeply unconscious at the home of a blonde girl friend in the Notting Hill section. He was pronounced dead after being taken in an ambulance to St. Mary Abbots Hospital.”


Maule noted the musician had stood trial in Toronto for possession of hashish and heroin, but, during court proceedings, admitted only to using “marijuana, hashish, LSD and cocaine” — “never heroin.”


Stressed from overwork, personal issues, and a less productive year than many previous, Hendrix officially died of a barbiturate overdose — murky and unrefined though the details therein remain.


Shining a rarely observant light on drug culture — incidentally, not long after President Richard Nixon’s drug chief rejuvenated the drug war as a political offensive against African Americans and cannabis users — Hendrix hammered home the perils and foolishness in deeming illegal choices an individual would make for themselves, alone, that would not harm another, stating,


“This I really believe: anybody should be able to think or do what they want as long as it doesn’t hurt somebody else.”



READ MORE:  Taxpayers Shell Out $100K to Pay for Cops Caught Eating Weed & Assaulting People in Pot Shop Video



Were that philosophy to append the mission of the war on drugs, the planet would almost certainly have witnessed fuller playlists from countless musicians — immediately springing to mind are Michael Jackson, Elvis Presley, Keith Moon, Jim Morrison, and Kurt Cobain.


That hardly scratches the surface.


Disparate genres, talents, and foibles aside, each musician — and ordinary person — falling victim to drug abuse, overdose, and death is subsumed and spit out as the troubled bones evincing predatory effects of the duopsony in the drug war and Big Pharma, still sealing authoritarian control of all illicit substances.



A perpetual, collective voice from these fallen icons past and future, emanates hauntingly from the grave — in a synchronicity not imagined, given their disparate genres — that to continue the war on drugs in perpetuity damns the world to future pain not justifiable by any definition.


Were the dangerous war on substances instead to focus its sights on the ills and issues making their ingestion an insurmountable temptation, the planet could step resoundingly closer to peace — peace, that is, set to music from the richly talented tapestry of artists whose only harm brought only their own ends.