Showing posts with label dioxins. Show all posts
Showing posts with label dioxins. Show all posts

Wednesday, July 5, 2017

Chemical Bioaccumulation Responsible for Immunotoxicity

Chemical Bioaccumulation Responsible for Immunotoxicity | chemical-weedkiller-pesticides | Environment Science & Technology Special Interests Toxins


Science is great when scientists use it to manufacture products that make our lives easier. But science can sometimes be the worst culprit when it is misused to hide the dangers that some chemicals pose to human health.


In the first article of this series, I demonstrated how easily chemicals get into the food supply and how every time humans, animals and the environment are exposed to them, disease is not only created but also continually fed.


In the second part of the Chemical Reality series I exposed what is perhaps the most dangerous chemical commonly found in products manufactured by the food industry.



Bisphenol A along with other synthetic chemicals are intentionally put in industrialized products by an industry that seems to be worried only about supplying a food market without taking into consideration that the chemicals used in the production of those industrialized products are destroying the environment and consequently our health.


One of those chemicals that circulate in our food supply are Dioxins, which is the second chemical in our list of the most dangerous ingredients. Dioxins are multi-tasker chemicals produced from the burning of chlorine and bromine. Just as BPA does, Dioxins disrupt the delicate hormonal balance in male and female organisms.


Even while exposed to very low levels of dioxins, this chemical endangers the life of an unborn children, damage sperm quality and count, and the bodies of pregnant mothers.


Research has found that dioxins bio-accumulate in organisms including humans, plants and animals, building up to levels that turn it into a dangerous carcinogen. Dioxins are powerful enough to disrupt the immune and reproductive systems.


As in the case of BPA, Dioxins act by interacting with a specific intracellular protein, which in turn causes disruptions on other regulatory proteins in organisms.


The aryl hydrocarbon (AH) receptor, the one that is most likely affected by dioxin toxicity, is involved in the expression of many genes.


Since many industrial by-products are identified as dioxins, it is not known which of those chemical compounds causes the most harm to organisms exposed to them, but it is abundantly clear that they are responsible for immunotoxicity endocrine effects, tumor promotion and toxic responses.


The damage caused on humans


Two of the main negative effects that dioxins have on humans are reproductive and developmental problems. Additionally, dioxins are also responsible for damage to the immune system, hormonal disruption and cancer.


While in unborn children heavy exposure to dioxins can be deadly, in adults the most common consequences are liver damage, alterations in heme metabolism, disruptions in serum lipid levels, thyroid functions, diabetes and immunological effects.


Perhaps the most studied effect of dioxins in the human body is their ability to cause cancer. Even the United States Environmental Protection Agency (EPA) has labeled dioxins as “likely human carcinogens”.


The International Agency for Research on Cancer classified dioxins as carcinogens type 1 because of their ability to accelerate formation of tumors and affect the mechanisms for inhibiting tumor growth.


It is important to highlight that in most of the Western world, both bromine and chlorine, whose industrialization process releases dioxins into the environment, are contained in bottled water which people purchase in supermarkets.


Some of the most powerful chemical companies such as Dow Chemical are heavily involved in the processing of chlorine.


This chemical is mainly used to manufacture plastics, chemical solvents, pesticides and other products that are also used in a number of industrial processes as well as in the production of supposed food items.


Because dioxins are a by-product released from the processing of other chemicals, it is easily found in plants and animals on which humans rely heavily for their nutrition.


That is why most of human exposure to dioxins comes from the intake of animals products like meat and dairy as well as fish, fruit and vegetables.


Even though some governments managed to decrease emissions of dioxins, bio-accumulation of this toxic chemical compound is likely to increase in humans between 20 and 60 years of age.


Among some of the most dangerous examples of dioxins are PCBs and PCDD/F-compounds, which spread around the environment during waste incineration, leakage during transportation, air circulation and of course soils that are contaminated with dioxins such as landfills, which in turn contaminate underground natural water depositories. Despite significant advances in dioxin sequestration, this chemical is still bio-accumulating in the environment and in our bodies.


Neither humans nor animals, not even microbes are able to get rid of dioxins in their organisms fast enough. In fact, dioxins are one of the most persistent toxic compounds in the environment.


As if its persistence and capacity to bio-accumulate were not bad enough, dioxins also possess the capacity to bio-magnify their effects. In other words, the concentration of dioxins can exceed its background persistence in humans, animals and the environment.


The capacity shown by dioxins to be persistent, to bio-accumulate and to bio-magnify its effects affects the whole food chain, from microbes to plankton that are later used as food by insects, animals as well as other flora and fauna that eventually becomes food.


Every time dioxins reach another level of the food chain their toxicity is multiplied, a fact that makes humans the most endangered receptor of dioxins because humans are at the top of the food chain.


A recent study performed by Professor Niels Skakkebaek, of Copenhagen University Hospital in Denmark, proves that endocrine disruptors such as dioxins have an even more dangerous effect on human health than first thought.


“For the first time, we have shown a direct link between exposure to endocrine-disrupting chemicals from industrial products and adverse effects on human sperm function,” says Skakkebaek.


The study also found that the accumulation of several kinds of endocrine disruptors cause what is called a “cocktail effect”, that is, the damage caused by unwanted chemicals in our bodies are exponentially higher than when they act alone.


This Danish study also determined that the concentration levels needed for chemicals to negatively impact sperm health and hormonal balance, for example, are very low, similar to the amounts found within the human body.


As per Professor Skakkebaek’s study, most of the chemicals that threaten human health are ingested or acquired through the use of everyday products such as soap, toothpaste, plastic containers and toys.


“In my opinion, our findings are clearly of concern as some endocrine-disrupting chemicals are possibly more dangerous than previously thought. However, it remains to be seen from forthcoming clinical studies whether our findings may explain reduced couple fertility which is very common in modern societies,”


Professor Skakkebaek told The Independent. According to him, at least one in three substances deemed as “non-toxic” actually have the power to greatly affect the potency of sperm cells, which could explain the high levels of infertility in humans.


According to the Centre of Advanced European Studies and Research in Bonn, Germany, some 30 of every 100 chemicals used in household products, which are considered safe, directly disrupt the “catsper” protein, that is the substance responsible for managing sperm motility, agility and ability to fertilize the female egg.


“In human body fluids, one does not find one of a few particular chemicals, but rather complex chemical cocktails with many different endocrine-disrupting chemicals at very low concentrations. We tried to mimic this situation in our experiments,” said Dr. Timo Strünker.


With some much evidence showing that dioxins are indeed a threat to human fertility and even fully grown human beings, there is not doubt that the best thing to do is avoid products that contain dioxins.


In fact, it is best to avoid processed, industrialized products completely. Because dioxins and other toxic chemicals are in plastic, cans and other types of wrappings that are used by the so-called food industry, the best way to eliminate exposure to dioxins is avoiding the consumption of all processed foods. Unfortunately, most people do exactly the opposite.


Having plenty of evidence about the dangers posed by chemicals in the food doesn’t seem to be enough for most people to stop eating out of cans, drinking from bottles or feeding themselves with heavily processed fast-food.


In fact, it seems like eating oneself to death is fashionable. For those who are into health rather than into fashion, here is a simple reason why it is necessary to eliminate processed foods once and for all: Processed foods are an illusion.


The use of words such as “healthy” on a can or a bottle as well as other like low fat, no carbohydrates, fortified, contains omega-3s, etc are all lies, because none of those ingredients, assuming they are actually present in the processed foods, are naturally obtained and added.


Take for example milk with added vitamin D. Most, if not all vitamin D added to milk is created by extracting materials from sheep’s wool. I am sure this fact comes as a shock to many.


In our next part of the series Chemical Reality I will continue shrinking the list of things that humans should ingest in order to remain healthy, with a very alarming trend towards the fact that there is very little in our diet that we should be eating and drinking.

Sunday, October 30, 2016

Terrifying Toxic Chemicals To Avoid This Halloween

halloween-candy-toxic-poison-chemicals


Halloween is creeping near, are you prepared? Before you make a mad dash to the nearest costume shop, consider this—do you know what’s in your costume? Your masks and makeup?


Terrifying toxins! Catastrophic chemicals! Horrifying harbingers of–ok, alright. You probably get the idea. Festive Halloween accouterments can be loaded with harmful chemicals and toxic metals. It can be difficult to resist a low-price costume produced with cheaply-sourced goods, but there are a few good reasons why you should consider more than price when deciding which Halloween products to buy.


Chemicals in Costumes, Accessories, and Decorations


Costumes, accessories, and decorations from most major national Halloween retailers contain chemicals and additives that have been linked to health issues such as reproductive problems, developmental delays, and even cancer.[1]


PVC, Phthalates, and Dioxins


In one evaluation of nearly 150 Halloween products, one-third contained PVC (polyvinyl chloride), a known endocrine disruptor.[1] Additionally, PVC fabric is frequently treated with chemicals known as phthalates. Children are susceptible to the ill-effects of phthalates which include premature puberty, birth defects, liver problems, and testicular cancer later in life.[2] PVC products also contain dioxins, chemicals that are classified carcinogens and cause reproductive issues and learning delays.[3]


Lead Contamination


Lead is another toxin that often contaminates cheap foreign goods, especially Chinese imports, including food and children’s toys.[4] It shouldn’t be a surprise that lead’s insidious reach extends to Halloween products. In 2012, the US federal government seized over 1400 Halloween costumes of Chinese origin due to lead levels that were 10 times higher than the allowed maximum.[5] Many lead-contaminated costumes or props have a piece or two that will, at some point, find its way into a child’s mouth. The seized items included pirate costumes that had an eye patch that contained over 40 times the legal maximum limit for lead.[6]


Lead poisoning is exceptionally hazardous to children. It interferes with calcium, is toxic to proteins, and has a severely negative effect on nerve function. Exposure to lead is even linked to cognitive and hearing impairment. Lead exposure threatens fetal development as well. Pregnant women who have been exposed to lead may experience miscarriage, premature birth, or have undersized babies.[7]


Flame Retardants


Fabrics that have been treated with flame retardants are another concern with respect to Halloween costume safety. Such fabrics are often contaminated with antimony[8] and other dangerous chemicals. Exposure to antimony trioxide, a common flame retardant applied to fabrics, is linked to sharp increases in peripheral arterial disease (PAD),[9] which is a condition that causes atherosclerotic plaque to form in the arteries.[10] Some flame retardants are especially dangerous to children because their chemical structure is similar to developmental neurotoxins, like organophosphate pesticides, which affect brain development.[11]


Toxic Makeup and Glow Sticks


toxic-chemicals-makeup-2-300x200Many people don’t consider that the skin is their largest organ and one of the first contact points for toxins. Makeup, in general, is something to watch out for, as toxic metals frequently contaminate cosmetics.[12, 13] Some face painting kits for children also contain high levels of lead, arsenic, mercury, cadmium, and antimony, all of which are especially toxic to the kidneys and the immune, reproductive, and nervous systems.[14]


Glow sticks and glow jewelry seem like a harmless way to stay visible while trick-or-treating, but the chemicals in those plastic tubes do pose a threat. Dibutyl phthalate (DBP) and anthracene, two chemicals found in glow sticks, can be poisonous. But, to be fair to glow sticks, the amount contained is usually too small to cause problems in humans. A more likely scenario is a child or pet getting DBP in their eyes, mouth, or on their skin. For children, the effects range from skin irritation or mild chemical burns to nausea and vomiting if ingested.[15] Pets have a similar reaction—they may drool profusely, retch, vomit, or paw at their mouths if they made the mistake of chewing on a stray glow bracelet.[16] A sick pet or child can ruin your evening, so forego the glow sticks or make sure no one tries to cut (or bite) them open.


How to Have a Healthy, Happy Halloween


We’re not here to ruin Halloween for you—we want you to have the safest, healthiest, and happiest Halloween possible! There are safe alternatives that render the hazardous options completely unnecessary. Of course, you could perform a full body detox, but reducing your exposure to toxins in the first place is a better strategy. When assembling your costume, examine the labels before purchasing. Or, better yet, make your own costumes and accessories yourself with non-toxic materials.


The Top 5 Ways To Ensure a Toxin-Free Halloween


  1. Look for makeup kits labeled non-toxic, and make sure they are produced in a country with strict regulations on consumer goods. Wash off makeup before bed.

  2. Wear a wig instead of temporary spray-on hair color, as they often contain VOCs.[17]

  3. Avoid plastic teeth as they tend to be softened with phthalates.[18]

  4. Check labels on costumes and accessories for vinyl (polyvinyl chloride or PVC) and flame retardants.

  5. Limit candy consumption, avoid corn syrup and synthetic food dyes.

Healthy Treats Are Important, Tootoxic-chemicals-healthy-food-300x200


Toxic costumes aren’t the only potential problem. Conventional Halloween fare is too sugary, over-processed, and full of preservatives and stabilizers. It’s difficult to resist all the Halloween cakes, cookies, and candy, but you can easily find recipes that recreate the traditional treats with legitimately healthy ingredients like cashews, chia seeds, and dark chocolate. Autumn is a time to be indulgent — in a healthy way. Try our dessert recipes for great-tasting and good-for-you alternatives, like the vegan custard-stuffed pumpkin.


Do you have any tips for enjoying a happy, healthy Halloween? Leave a comment below and share your thoughts.


References


  1. “Halloween Study.” 2014. Web. 13 Oct. 2016.

  2. Johnson. PVC – a major source of phthalates. n.d. Web. 13 Oct. 2016.

  3. “Polyvinyl Chloride (PVC) – toxic chemicals and environmental health risks where you live and work – text version.” 27 June 2016. Web. 13 Oct. 2016.

  4. Berman, Barry, and Kunal Swani. “Managing product safety of imported Chinese goods.” Business Horizons 53.1 (2010): 39–48. Web. 13 Oct. 2016.

  5. International, Public Radio. Chinese-made Halloween costumes recalled for high lead content. Public Radio International, 13 Oct. 2016. Web. 13 Oct. 2016.

  6. “Lead-contaminated pirate costumes seized.” NBCNews.com, n.d. Web. 13 Oct. 2016.

  7. “Lead – toxic chemicals and environmental health risks where you live and work – text version.” 31 Mar. 2016. Web. 13 Oct. 2016.

  8. Cooper, Ross G., and Adrian P. Harrison. “The Exposure to and Health Effects of Antimony.” 13.1 (2009): n.pag. Web. 13 Oct. 2016.

  9. “The exposure to and health effects of antimony.” 13.1 (2009): n.pag. Web. 13 Oct. 2016.

  10. “What Is Peripheral Artery Disease? – NHLBI, NIH.” Google+, 22 June 2016. Web. 13 Oct. 2016.

  11. Grossman, Elizabeth. Are Flame Retardants Safe? Growing Evidence Says “No”. Yale environment 360. 2008. Web. 13 Oct. 2016.

  12. Troubling levels of toxic metals found in cosmetics. UC Berkeley School of Public Health, 2016. Web. 13 Oct. 2016.

  13. Bocca, B, et al. “Toxic Metals Contained in Cosmetics: A Status Report.” Regulatory toxicology and pharmacology : RTP. 68.3 (2014): 447–67. Web. 13 Oct. 2016.

  14. Schmidt, Sarah. Heavy metals found in kids’ face paints. www.canada.com, 1 Feb. 2009. Web. 13 Oct. 2016.

  15. Campbell, Olivia. Party Poopers: Are Glow Sticks Party Killers? 23 Sept. 2014. Web. 13 Oct. 2016.

  16. Coffin, Anna. 13 household items toxic to pets. 2016. Web. 13 Oct. 2016.

  17. “Volatile Organic Compounds (VOCs) in Commonly Used Products.” July 2013. Web. 13 Oct. 2016.

  18. Reports, 2016 Consumer. Ten tricks for a safe and “green” Halloween. 23 Sept. 2014. Web. 13 Oct. 2016.

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