Showing posts with label Clostridium difficile. Show all posts
Showing posts with label Clostridium difficile. Show all posts

Sunday, July 23, 2017

Sandbox Sickness: Diarrhea-Causing Bacteria Found on Playgrounds

A small study by researchers in Spain finds that dangerous germs are lurking on playgrounds. [1]


For the study, a team of scientists tested sandboxes and searched for Clostridium difficile, or C. diff. They found it alright, and it was the drug-resistant variety.


C. diff is usually considered a hospital-acquired infection; but the rates of infection outside of hospitals are increasing, the authors of the study write.




One possible source of C. diff exposure is sandboxes, the researchers found. The bacterium may wind up there from the feces of humans and other animals. (Cats + sand = litter box.) The bug can survive for weeks or months outside of the body.


C. diff in sandboxes is especially dangerous for young children, the primary group at risk of catching the bug from playgrounds. Why? Because kids have high rates of geophagia. In other words, they eat sand and dirt.


Studying the Nitty-Gritty of C. Diff in Sandboxes


For the study, researchers tested sand from 40 sandboxes in public parks in Madrid, Spain, including 20 that were designated for children and 20 that were for dogs. C. diff was found in 9 of the sandboxes intended for kids, and 12 of the sandboxes intended for dogs.


An analysis of the different C. diff strains revealed that 2 of the samples from the kids’ sandboxes and 6 samples from the dogs’ sandboxes had “toxigenic” strains, meaning that they produced toxins. These toxins can lead to a damaged colon lining and diarrhea. Some strains of C. diff produce more toxins than others.


Every sample that the researchers tested was resistant to at least 2 antibiotics, making the infection more difficult to treat.


Read: Dutch “Poop Bank” Will Offer Treatment, Research of C. Diff as Antibiotics Fail


The researchers wrote that because of the risks posed by C. diff, tests for the bacterium should be included in future environmental-risk assessments.


Lead researcher Dr. Jose Blanco, from the Department of Animal Health at Complutense University of Madrid, said:


“This study shows the wide distribution of [these] bacteria in the environment, and the need for more studies to elucidate its presence in our communities.” [2]


Past studies in the U.S. have found other pathogens in sandboxes, including Toxoplasma gondii, which can cause flu-like symptoms, and parasitic Ascaris (nematode worm) eggs that can cause abdominal discomfort.


If you’re not totally disgusted yet, this should do it: Different types of roundworms have been found in playgrounds. Baylisascaris procyonis, spread by raccoons, can cause neurological damage and death. Thankfully, it’s extremely rare. Then there’s Toxocara roundworms – these stomach-turning creatures cause about 70 cases of blindness in U.S. children each year.


About Clostridium Difficile


Source: Medical News Today

C. diff infection can be hard to treat. The bacteria cause an intestinal infection that can lead to severe diarrhea which, in turn, can lead to dangerous dehydration. The symptoms of mild to moderate C. diff infection typically include:


  • Watery diarrhea 3 or more times a day

  • Mild abdominal cramping and tenderness [3]

Serious infections can cause:


  • Watery diarrhea 10 to 15 times a day

  • Abdominal cramping and pain, which may be severe

  • Rapid heart rate

  • Fever

  • Blood or pus in the stool

  • Nausea

  • Dehydration

  • Loss of appetite

  • Weight loss

  • Swollen abdomen

  • Kidney failure

  • Increased white blood cell count [3]

Severe complications can arise from C. diff infection, including:


  • Toxic megacolon, a condition in which the colon is unable to expel gas and stool, causing it to become greatly distended (megacolon). If not treated in time, the colon can rupture, causing bacteria from the colon to enter the abdominal cavity, requiring emergency surgery. Toxic megacolon is sometimes fatal.

  • Bowel perforation, a rare condition caused by extensive damage to the lining of the large intestine or after toxic megacolon.

A single course of antibiotics can cause C. diff. infection.




How to Prevent C. Diff Infection


To help prevent your little ones from getting sick from sandboxes, the American Academy of Pediatrics recommends:


  • Keeping sandboxes covered when not in use to keep insects and animals out.

  • Letting sand dry before covering the sandbox, as wet sand is an ideal place for bacteria to grow.

  • Raking the sand regularly to remove debris, clumps, and other foreign material.

  • Not allowing pets to play in the sandbox… for the obvious reasons. [2]

Sources:


[1] Live Science


[2] CBS News


[3] Mayo Clinic


Medical News Today



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About Julie Fidler:


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Julie Fidler is a freelance writer, legal blogger, and the author of Adventures in Holy Matrimony: For Better or the Absolute Worst. She lives in Pennsylvania with her husband and two ridiculously spoiled cats. She occasionally pontificates on her blog.

Thursday, May 25, 2017

Gene-Editing Technology may Replace Antibiotics in the Future

Doctors and researchers are in a race against the clock to find new antibiotics and alternatives to antibiotics as the problem of drug-resistance worsens and spreads. One bacterial superbug in particular which has researchers especially worried is Clostridium difficile, or C. difficile – a bacterium which can cause fatal infections in hospitals and nursing homes. Scientists are now working on a “pill” that uses CRISPR gene-editing technology to kill the harmful bacteria. [1]


Considered a probiotic, the technology is still in its infancy and is yet to be tested on animals. Jan-Peter van Pijkeren, a food scientist from the University of Wisconsin-Madison who is the creator of the CRISPR pill (which could also be given in liquid form), says:


“The downside of antibiotics is they are a sledgehammer that depletes and destroys the gut microbial community. You want to instead use a scalpel in order to specifically eradicate the microbe of interest.”





The idea behind using CRISPR to defeat antibiotic-resistant bacteria is that it could kill a single species of germ while leaving the beneficial bacteria unharmed.


Herbert DuPont, director of the Center for Infectious Diseases at the University of Texas, says:


“As long as we house patients together in a hospital or in a nursing home and we give a lot of them antibiotics we’re going to have a problem with C. difficile.”


Here’s how it works:


  • Van Pijkeren plans to create a virus that can carry a customized CRISPR message into the body via the probiotic liquid or pill.

  • When it passes into the intestinal tract, the virus would exit and infect the C. difficile.

  • The “message” in the pill then causes the bacteria to self-destruct. [2]

The Technology Doesn’t Come Without Worry


Though some are excited about such advancements, there are some inherent risks in using CRISPR-Cas9 technology to edit the human genome, or other living organisms that interact with the human body and our ecosystems at large. Gang Bao, a professor of bioengineering at Rice University, explains that unwanted gene edits, called off-target effects, “could influence the function of many genes, possibly posing serious health problems.”


Bao adds:


“In the germline, off-target effects might persist for generations and could lead to long-term changes in the genome.”


The so-called CRISPR pill that researchers are now championing would be designed to leave “good” bacteria untouched. So far, there has been no mention of the risks associated with the technology but that doesn’t mean scientists aren’t concerned.


Unless (or until) we encounter serious issues concerning CRISPR technology on a larger scale, it seems that this advancement in science is continuing at full speed, so it is essential that we consider all the possibilities and weigh the risks and potential benefits properly. Hopefully we’ll take more precautions than we did with speedily approving genetically modified foods, as any change of this scale requires in-depth controlled research, analysis, and most of all, time.


Sources:


[1] Futurism


[2] Digital Trends



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About Mike Barrett:


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Mike is the co-founder, editor, and researcher behind Natural Society. Studying the work of top natural health activists, and writing special reports for top 10 alternative health websites, Mike has written hundreds of articles and pages on how to obtain optimum wellness through natural health.