Showing posts with label patients. Show all posts
Showing posts with label patients. Show all posts

Monday, April 16, 2018

Goldman Sachs Analyst: Curing Patients Not a Sustainable Medical Business Model

Goldman Sachs Analyst: Curing Patients Not a Sustainable Medical Business Model | medical-doctor-money | Economy & Business General Health Medical & Health Sleuth Journal Special Interests


By Carey Wedler, The Anti-Media



One of the most reviled companies in the United States recently gave Americans yet another reason to distrust their power: A recent Goldman Sachs report reveals the company questioning whether or not curing chronic illness is compatible with a sustainable business model.


In an internal report viewed by CNBC about the potential of the biotech industry and gene therapy titled “The Genome Revolution,” analysts asked: “Is curing patients a sustainable business model?”


“The potential to deliver ‘one shot cures’ is one of the most attractive aspects of gene therapy, genetically-engineered cell therapy and gene editing,” wrote analyst Salveen Richter. “However, such treatments offer a very different outlook with regard to recurring revenue versus chronic therapies,” analyst Richter wrote in the April 10 report.


“While this proposition carries tremendous value for patients and society, it could represent a challenge for genome medicine developers looking for sustained cash flow.“


Richter cited a Hepatitis C drug manufactured by Gilead Sciences that achieved a 90% cure rate. As CNBC noted:


“The company’s U.S. sales for these hepatitis C treatments peaked at $12.5 billion in 2015, but have been falling ever since. Goldman estimates the U.S. sales for these treatments will be less than $4 billion this year, according to a table in the report.”


In light of the reduced profits as a result of the success of the drug, Richter wrote:


“GILD is a case in point, where the success of its hepatitis C franchise has gradually exhausted the available pool of treatable patients. In the case of infectious diseases such as hepatitis C, curing existing patients also decreases the number of carriers able to transmit the virus to new patients, thus the incident pool also declines … Where an incident pool remains stable (eg, in cancer) the potential for a cure poses less risk to the sustainability of a franchise.”


Indeed, cancer is a highly profitable disease. In 2015, the world spent $107 billion on cancer drugs, and according to 2016 projections, that number was expected to grow to $150 by 2020. Further, Gilead Sciences, which Richter singled out as a company losing profits due to cures, was still the second-most profitable pharmaceutical/biotech company in the world in 2017, earning over $12 billion in net income.


Richter, who did not respond to CNBC’s request for comment, offered several ideas to cope with the ‘problem’ of healing patients. He suggested targeting large markets, such as those suffering from hemophilia, because “Hemophilia is a $9-10bn WW market (hemophilia A, B), growing at ~6-7% annually.” in addition, he advised clients to target disorders with high incidences, such as spinal dystrophy, as well as focus on “[c]onstant innovation and portfolio expansion.”


Additionally, Ars Technica reported, the analysis “hints that, as such cures come to fruition, they could open up more investment opportunities in treatments for ‘disease of aging.’”


Goldman Sachs confirmed the authenticity of the report to Ars Technica but declined to comment on its contents.




The post Goldman Sachs Analyst: Curing Patients Not a Sustainable Medical Business Model appeared first on The Sleuth Journal.

Wednesday, February 7, 2018

Snooping Scientists Find DNA In Hospital Pipes That FUEL SUPERBUGS

superbug


The pipes of hospitals carrying away the infections of the sick are bound to be quite disturbing places. But scientists dared to snoop around in them anyway and found that they can fuel superbugs.


In a new study, published by The American Society for Microbiologyscientists determined that antibiotic-resistant bacteria are bred in the plumbing of hospitals. The study, titled Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of Bacterial Plasmids Conferring Carbapenem Resistance found that even when hospitals themselves are impeccably clean of infectious bacteria and viruses, the pipes that carry away those micro-organisms are not.


Even when the sinks, faucets, bedrails and countertops of patients’ rooms are largely free of germs that resist modern medicines, the genetic building blocks for antibiotic resistance intermingle freely in the pipes connected to those rooms, according to a study published Tuesday in the journal mBio. That DNA can give superbugs the power to defeat modern medicines and threaten the lives of patients. –LA Times


The DNA scientists were able to swab from the inside of the pipes showed that these little organisms have the power to become vast medicine-resistant superbugs that could wipe out a lot of people. The study began back in 2012 after a severely ill woman carried a bacterial infection into a New York health care center.


In 2012, a team of sleuths at the National Institutes of Health’s Clinical Care Center broke new ground in the effort to rout a deadly antibiotic-resistant infection that sickened at least 17 patients — and killed six — during the summer of 2011. Using whole-genome sequencing for the first time in such an investigation, the team identified the culprit: a super-potent strain of Klebsiella pneumoniae bacteria carried into the center by a seriously ill woman from New York.


The microbe, they discovered, was probably traveling between rooms after lodging in sinks and drains. Some were ripped out and others were sanitized in an extensive eradication effort.  –LA Times


The study itself came to the following conclusion:


Carbapenemase-producing organisms (CPOs) are a global concern because of the morbidity and mortality associated with these resistant Gram-negative bacteria. Horizontal plasmid transfer spreads the resistance mechanism to new bacteria, and understanding the plasmid ecology of the hospital environment can assist in the design of control strategies to prevent nosocomial infections. A 5-year genomic and epidemiological survey was undertaken to study the CPOs in the patient-accessible environment, as well as in the plumbing system removed from the patient. This comprehensive survey revealed a vast, unappreciated reservoir of CPOs in wastewater, which was in contrast to the low positivity rate in both the patient population and the patient-accessible environment. While there were few patient-environmental isolate associations, there were plasmid backbones common to both populations. These results are relevant to all hospitals for which CPO colonization may not yet be defined through extensive surveillance.-American Society for Microbiology


During the study, all of the samples drawn from the piping system leading from the ICU tested positive for bacterial plasmids that confer resistance to carbapenems. And so did all seven samples drawn from wastewater samples taken from two external manholes associated with the NIH Clinical Center.


This means that hospital pipes can be the breeding grounds for the next superbug, and once infected, could eliminate up to 50% of those who become infected with the superbug.

Wednesday, January 31, 2018

Good Medicine: Do As Much Nothing As Possible

Good Medicine: Do As Much Nothing As Possible | doctors_doing_nothing | Big Pharma General Health Medical & Health Sleuth Journal Special Interests


”The delivery of good medical care is to do as much nothing as possible”


~ Samuel Shem, The House of God


Medicine is undergoing an existential crisis today. Its core value proposition – to help and not hurt — is failing to manifest. Patients are suffering. Doctors are suffering. The only exuberant party on the battlefield against disease is the pharmaceutical industry. An industry whose annual causalities far exceed the death total from our two decade long involvement in the Vietnam war.


The entire system is on the precipice of a collapse, if not for economic reasons alone, then certainly for ethical and intellectual ones. The irony is that the system has become so ineffective and dangerous that avoiding medical treatment (excluding perhaps emergency care) has become one of if not the best healthcare strategy you can implement to protect your health and well-being.


Nowhere is this clearer than in the realm of cancer. Over the past few decades, billions have been spent on screening asymptomatic populations to “prevent cancer,” with the result that millions have been assigned with questionable diagnoses (e.g.,”early stage-” or “stage zero-cancers”) and then shepherded into chemo, radiation and surgery treatments as if watchful waiting, or better yet, making significant nutritional and lifestyle modifications, would be a suicidal approach vis-à-vis the inexorability and presumed lethality of genetically-determined cancer.


We needn’t detail the misery this approach has produced, but suffice it to say that despite the industry’s claims of thousands of “lives saved” from the detection of “early cancers,” breast and prostate cancer specific mortality has at best stayed the same, and may have actually increased in some cases. In light of the fact that the financial costs of misapplied treatment in some cases is so high that the uninsured, their families, and society as a whole, face bankruptcy, the situation is dire indeed.


Even after the cat was let out of the bag in 2013, and a National Cancer Institute commissioned expert panel concluded that labeling screening detected lesions known as ductal carcinoma in situ (DCIS) and high-grade intraepithelial neoplastic hyperplasia (HG-PIN) (colloquially labeled as “breast cancer” and “prostate cancer,” respectively) as carcinomas (“cancer”) is no longer justified. Instead they opted for redefining what were previously considered potentially lethal cancers as “benign or indolent lesions of epithelial origin.” Yet, you hear virtually no mention of this change anywhere. Tens of thousands are still being diagnosed with the same “cancers” and being cut, poisoned and burned, without informed consent.


The lack of acknowledgment and discussion about these tremendous diagnostic “errors” is less surprising when you consider that about 1.3 million U.S. women were wrongly treated for breast cancer in the past 30 years, with prostate and lung cancer representing two additional icebergs upon which the Titanic cancer industry is presently running itself aground upon, regardless of whether the medical establishment will accept responsibility. Ignoring the truth that millions suffered needlessly, it would seem, is less painful than admitting wrong, and dealing with the psychological and financial fallout that inevitably follows. But is it possible to stem the tide much longer against the inevitable transformations brewing?


If you check the pubmed.gov statistics, interest in “overtreatment” and “overdiagnosis” has grown exponentially from only a few decades ago, when the terms were rarely mentioned. A new editorial, titled,  “It Is Overtreatment, Not Overdiagnosis,” points out the real issue behind the epidemic of cancer overdiagnoses:



The most widely accepted definition of ”overdiagnosis” is ”diagnosing a person without symptoms with a disease that will (ultimately) never cause symptoms or death during the person’s lifetime” (2). It should not be confused with misdiagnosis or false-positive findings, which are completely different entities and outside the scope of this commentary. As the generally accepted definition encapsulates downstream effects (ie, ”would otherwise not go on to cause symptoms or death”, the real issue lies with ”overtreatment” of these accurate diagnoses rather than overdiagnosis itself.



Overtreament does not happen in a vacuum. The very industries that produce the treatments also create and supports the “awareness campaigns” that not only use fear to corral the population into screening, but also “pinkwash” away their true causes, i.e. breast cancer awareness month talks about needing a cure but not the causes right under our noses (i.e. carcinogens). Therefore, the more diagnoses that are generated, the more treatments will be “recommended,” resulting in greater revenue and profit – an economic growth model that itself can only be described as a malignant process at least as violent, if not more, than the disease it is claiming to treat and manage.


The editorial concluded:



“The effects of treating inconsequential lesions, rather than their diagnosis per se, result in increased morbidity and cost without added benefit. Society as a whole should strive to treat individuals who should be treated and not those who would not benefit. The 13th law of Shem, true in 1978, remains true today.”



Essentially, modern medicine has become our most Orwellian institution, with “detecting cancer early” the biomedical equivalent of the Thought Police detecting crime before it happens. The prognosticating itself,  is a highly toxic process (nocebo: e.g., “You have cancer and 6 months to live.”) that can contribute to evoking cancer-promoting physiological reactions, as well as inflicting real psychospiritual wounds that have been determined to dramatically increase the risk of heart-related deaths and suicides. Medicine has also adopted the metaphorics of another powerful global force: the military industrial complex, with the cancer “prevention” being equated to “striking first,” eerily similar to the Bush doctrine of preemptive war to secure peace. Here, the precautionary principle is co-opted and inverted from its true meaning. Instead of “doing no harm,” unnecessary medical intervention is considered the only non-violent solution even when the collateral damage is so great that the patient often dies from the violence of “treatment” with weapons-of-mass-destruction grade radioisotopes and chemicals and not the condition.


We need to completely rethink medicine’s role in healing. What happens when we return to the fundamentals of an entity – the human, soul and body together — whose self-healing capabilities are so powerful that even the suggestion through sugar pill or kind word of a health practitioner that a disease can attenuate or disappear actually causes significant improvement? What if given the right conditions – clean air, water, food and a healthy environment, physically and emotionally – the conditions for disease were suddenly removed, and replaced with an opposite environs promoting health? If medicine makes it through the birth process of its own existential crises, these principles will invoke an entirely new medical model where the placebo effect is not to be “controlled for,” but liberated and expanded by educating the patient to the fact that they can and do heal themselves, mainly by avoiding medical treatment and doing the right amount of nothing.


© January 30, 2018 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here http://www.greenmedinfo.com/greenmed/newsletter.


The post Good Medicine: Do As Much Nothing As Possible appeared first on The Sleuth Journal.

Sunday, May 21, 2017

Getting a Second Opinion About Health Issues Could Save Your Life

You shouldn’t take one doctor’s word for it when they diagnosis an illness, as 88% of patients who seek a second opinion receive a new or revised diagnosis. Another 21% of patients receive a “distinctly different” diagnosis, meaning the first doctor’s diagnosis wasn’t even in the ballpark, a recent study says. [1]


Doctors confirm diagnoses in just 12% of cases, according to researchers, who detail their findings in the Journal of Evaluation in Clinical Practice.


Receiving a second opinion could be vital for patients to receive accurate and timely treatment of what ails them, and prevent unnecessary treatments.




Related: 1 in 5 Children are Improperly Diagnosed with ADHD


In a statement, lead researcher James Naessens, Sc.D., a health care policy researcher at Mayo Clinic, says:


“Knowing that more than 1 out of every 5 referral patients may be completely [and] incorrectly diagnosed is troubling — not only because of the safety risks for these patients prior to correct diagnosis, but also because of the patients we assume are not being referred at all.”


Sometimes, it may even be important to seek a third opinion, according to Dr. David Agus.


“Obviously you want to get the right diagnosis so you can have the right treatment and there’s no way to treat effectively unless you know what you’re up against.”


Good Intentions, Bad Diagnosis


For the study, physicians at the Mayo Clinic looked at the medical records of 286 patients who visited a primary healthcare provider between 2009 and 2010. Each patient sought a second opinion, either because they were urged to do so, or they took the initiative on their own. [2]


  • Just 12% of the patients were given the same diagnosis after seeking a second opinion

  • 66% of patients had a slightly altered diagnosis

  • Approximately 1/5 received a completely different diagnosis from the original.

69264331 – senior medics looking puzzled over xray

Read: Study Suggests Patients may be Able to Predict Illness Better than Doctors


If you’ve ever visited a diagnostic site like WebMD, then you probably already know that symptoms almost never apply to only 1 condition. There are thousands of diseases and only hundreds of symptoms, and the symptoms of different diseases often mimic each other.


For example, pancreatitis and pancreatic cancer share many of the same symptoms. Similarly, many people miss the signs of a heart attack because the symptoms can be similar to a stomach virus.


Previous research shows that diagnostic errors “contribute to approximately 10% of patient deaths” and “account for 6-17% of adverse events in hospitals.” [3]


Mark L. Graber, a senior fellow at the research institute RTI International and founder of the Society to Improve Diagnosis in Medicine, says:


“Doctors are humans, and they make the same cognitive mistakes we all make. If you are given a serious diagnosis, or you’re not responding the way you should [to medication], a second opinion is a very good idea. Fresh eyes catch mistakes.”


Sources:




[1] CBS News


[2] Quartz


[3] The Washington Post



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About Mike Barrett:


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Mike is the co-founder, editor, and researcher behind Natural Society. Studying the work of top natural health activists, and writing special reports for top 10 alternative health websites, Mike has written hundreds of articles and pages on how to obtain optimum wellness through natural health.